Makale detayı · 2023
Design, synthesis, and biological evaluation of indole-modified tamoxifen relatives as potent anticancer agents
Royal Society of Chemistry (RSC)
YÖKSİS
OpenAlex
Açık erişim · green
SJR Q1
JCR Q2
Atıf 11
Yüzdelik 89.5%
FWCI 2.45
- Yıl
- 2023
- ISSN
2632-8682- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
selectively reduced the viability of receptor-sensitive breast cancer cells more effectively than tamoxifen and suppressed the expression of ER-regulated genes. Moreover, Caspase-8 activity showed a specific increase in MCF-7 cells treated with these compounds. Our results indicate that these compounds may be an alternative to tamoxifen for the treatment of breast cancer.
Konular
- Estrogen and related hormone effects
- Bioactive Compounds and Antitumor Agents
- Inflammatory mediators and NSAID effects
Birincil konu Estrogen and related hormone effects