Makale detayı · 2015
Overexpression of miR 145 5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression
YÖKSİS
OpenAlex
SJR Q1
JCR Q3
Atıf 88
Üst %10
Yüzdelik 92.3%
FWCI 3.1
- Yıl
- 2015
- ISSN
0735-7907- Tür
- article
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Özet
İngilizce (OpenAlex)
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.
Konular
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
Birincil konu MicroRNA in disease regulation