Makale detayı · 2007
Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas
Balkan Journal of Medical Genetics
- Yıl
- 2007
- ISSN
1311-0160- Tür
- article
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Özet
İngilizce (OpenAlex)
Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas Development and progression of human malignancies involve multiple genetic changes including chromosomal instabilities such as translocations, deletions, and inversions. Chromosomal abnormalities were observed in 23 cases with ovarian and endometrial cancer by cytogenetic studies using a GTG (G bands by trypsin using Giemsa) banding technique. Specific chromosome bands were frequently involved, and were most frequent on chromosomes 1, 2, 3, 5, 12 and 17. Clonal alterations were observed at the cancer breakpoints, such as 1q21, 1q32, 3p21, 7q22, 11q23 in ovarian and 1p36, 1q32, 2p12, 3p21, 7q22, 9q34, 11p15, 11q23, 12q13, 14q11, 14q32, 16p13, 21q22 in endometrial cases. These findings provide evidence that multiple genetic lesions are associated with the pathogenesis of endometrial and ovarian cancer.
Konular
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Genetic factors in colorectal cancer
Birincil konu Cancer Genomics and Diagnostics