Makale detayı · 2021
Regiones organizadoras nucleolares argirófilas como un biomarcador esperanzador para la detección de niveles de hipoxia cerebral causados por diferentes dosis de intoxicación de monóxido de carbono
- Yıl
- 2021
- ISSN
0016-3813- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Objectives: The purpose of the study is to investigate whether there is any relationship between mean argyrophilic nucleolar organizing regions (AgNOR) number and total AgNOR area/total nuclear area (TAA/TNA) ratio and the levels of brain hypoxia after exposure to different acute doses of carbon monoxide (CO) gas.Methods: Each experimental group was exposed to CO gas (concentrations of 1,000, 3,000 and 5,000 ppm).Then, the rats were anesthetized, and blood samples were taken from the right jugular vein for carboxyhemoglobin levels detection.The rats were sacrificed on seventh day.AgNOR staining was applied to brain tissues.TAA/TNA and mean AgNOR number were detected for each nucleus.Results: Significant differences were detected among all groups for TAA/TNA ratio, mean AgNOR number and carboxyhemoglobin level.According to a double comparison of groups, the differences between control and 1,000 ppm, control and 3,000 ppm, control and 5,000 ppm, and between 1,000 and 5,000 ppm were significant for TAA/TNA ratio.When mean AgNOR number was considered, significant differences were detected between control and 1,000 ppm, control and 3,000 ppm, control and 5,000 ppm, and between 1,000 and 3,000 ppm.Conclusion: AgNOR proteins may be used for early detection of the duration, intensity, and damage of brain injury caused by CO poisoning.Thus, effective treatment strategies can be developed for the prevention of hypoxic conditions.
Konular
- Health, Environment, Cognitive Aging
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
Birincil konu Health, Environment, Cognitive Aging