Makale detayı · 2023
The role of eNOS gene polymorphisms on contrast induced nephropathy development in chronic kidney disease patients
Therapeutic Apheresis and Dialysis
- Yıl
- 2023
- ISSN
1744-9979- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
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Özet
İngilizce (OpenAlex)
INTRODUCTION: Contrast nephropathy is a result of contrast media given through intravascular routes. Nitric oxide gene polymorphisms may alter the hemodynamic stability resulting in medullary ischemia Nitric oxide gene polymorphisms may have an enhancing role in contrast media related renal injury. The aim of this study was to investigate the role of eNOS intron 4a/b, T786C, and G894T gene polymorphisms on contrast-nephropathy risk. METHODS: Ninety-four chronic kidney disease patients with contrast nephropathy and 120 chronic kidney disease patients without contrast nephropathy were included. DNA isolation was performed and specific regions of DNA for eNOS G894T, T786C, and intron 4a/b genes were amplified by polymerase chain reaction technique. RESULTS: TT polymorphism of T786C gene and GG polymorphism of G894T gene were detected to be possibly protective from contrast induced nephropathy. CONCLUSION: Endothelial nitric oxide synthase G894T gene polymorphisms, older age, and presence of diabetes mellitus may influence contrast nephropathy development.
Konular
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Chronic Kidney Disease and Diabetes
Birincil konu Acute Kidney Injury Research