Makale detayı · 2006
Relationship between cytokines and tumour markers in patients with chronic heart failure
- Yıl
- 2006
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı EUROPEAN JOURNAL OF HEART FAILURE
- Katalog eşleşmesi (ISSN) European Journal of Heart Failure
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
AIMS: Serum levels of some cytokines and tumour markers are elevated in patients with chronic heart failure (HF). We aimed to investigate the relationship between circulating levels of cytokines and tumour markers in patients with HF. METHODS: We included 35 HF patients and 33 normal controls. HF patients were divided into two groups: mild HF (NYHA class I/II) (n=10) and severe HF (NYHA class III/IV) (n=25). Serum cytokine levels (TNF-alpha, IL-1 beta, IL-6, and IL-10) were measured by ELISA and tumour markers (CA 125, CA 19-9, CA 15-3, CEA and AFP) by chemiluminescent enzyme immunoassay. RESULTS: Serum levels of TNF-alpha, IL-6, and IL-10 as cytokines, and CA 125 and CA 19-9 as tumour markers were significantly higher in HF patients than in normal controls (p<0.0001 for all). Serum levels of TNF-alpha, IL-6 and IL-10 and CA 125 in the severe HF patients were significantly higher than in the mild HF patients (p<0.001 for all). Correlation analysis showed that CA 125 was positively related to TNF-alpha (r=0.624, p<0.001), IL-6 (r=0.671, p<0.001), and IL-10 (r=0.545, p<0.001) in HF. CONCLUSION: These findings show that CA 125 is markedly elevated in patients with HF, and correlates with serum TNF-alpha, IL-6 and IL-10 levels. Therefore, we speculate that among the tumour markers studied, only CA 125 is closely related to the cytokine system.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
110 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 11 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Serum Carbohydrate Antigen 125 Levels in Advanced Heart Failure: Relation to B-Type Natriuretic Peptide and Left Atrial Volume 2008
- CA125 levels among patients with advanced heart failure An emerging independent predictor for survival 2010
- Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis 2018
- Elevated carbohydrate antigen 125 levels in hypertrophic cardiomyopathy patients with heart failure 2007
- Prognostic value of pleural effusion, CA-125 and NT-proBNP in patients with acute decompensated heart failure. 2010
- CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis 2013
- Serum Carbohydrate Antigen 125 Levels in Nonischemic Dilated Cardiomyopathy A Useful Biomarker for Prognosis and Functional Mitral Regurgitation 2012
- Serum Carbohydrate Antigen 125 Levels in Nonischemic Dilated Cardiomyopathy A Useful Biomarker for Prognosis and Functional Mitral Regurgitation 2012
- Serum Carbohydrate Antigen 125 Levels in Nonischemic Dilated Cardiomyopathy: A Useful Biomarker for Prognosis and Functional Mitral Regurgitation 2011
- CA 125 and heart failure 2011