Makale detayı · 2025
Investigation of the antibacterial activity of Rhamnus cathartica L. and its anti-QS potential on Pseudomonas aeruginosa PAO1
- Yıl
- 2025
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Natural Product Research
- Katalog eşleşmesi (ISSN) Natural Product Research
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
The study aims to evaluate the Quorum Sensing (QS) system inhibition against some Gram-positive and Gram-negative bacteria detected by molecular modeling of R. cathartica L. plant extract. R. cathartica L. methanol extract was evaluated in vitro. R. cathartica L. extract was observed to have antimicrobial activity against Gram-positive and Gram-negative bacteria at different rates (11.3 mm-16 mm). The inhibitory effect of R. cathartica L. extract on P. aeruginosa PAO1 (elastase 61%, pyocyanin 18%, and biofilm 61%) was recorded moderately. Phytochemical analysis revealed that the main component of the extract is kaempferol. Therefore, the binding potential of kaempferol on QS system receptors was investigated via molecular docking. Computational analysis showed that kaempferol can inhibit the QS system by preventing competitive ligands from connecting to LasR. It may provide a new way to use R. cathartica L. seed extract as a green antibacterial agent.
Konular
- Essential Oils and Antimicrobial Activity
- Bacterial biofilms and quorum sensing
- Medicinal Plants and Neuroprotection
Birincil konu Essential Oils and Antimicrobial Activity