Effects of FTO Gene rs9939609 and rs17817449 Polymorphisms on Insulin Resistance in Turkish Children With Obesity

İngilizce (OpenAlex)

BACKGROUNDS: Fat mass and obesity-related gene (FTO) has been associated with glucose homeostasis and insulin sensitivity in some populations. The aim of this study was to evaluate the association of FTO gene rs9939609 and rs17817449 polymorphisms with insulin resistance, some cardiometabolic parameters, and body mass index (BMI) in Turkish children with obesity. METHODS: The cross-sectional observational study included 83 children with obesity genotyped for variants of the FTO gene (rs9939609 and rs17817449). Children were divided into two groups as control and insulin resistant according to the homeostatic model assessment of insulin resistance (HOMA-IR). The relationship between the genotypes of rs9939609 and rs17817449 polymorphisms and insulin resistance was determined using binary logistic regression analysis. RESULTS: In the control group and insulin-resistant obese group, the majority of the rs9939609 polymorphism was AT (69.2%) and AA (64%) genotypes, and the majority of the rs17817449 polymorphism was GT (65.4%) and TT (70%) genotypes, respectively. Fasting glucose and insulin values were lower, and quantitative insulin sensitivity calculation index (QUICKI) values were higher in the risk genotype (GG) of rs17817449 polymorphism (p < 0.05). Additionally, rs9939609 (AT genotype, OR = 0.063; 95% CI: 0.006-0.707, p = 0.025 and AA genotype, OR = 0.111; 95% CI: 0.021-0.576, p = 0.009) and rs17817449 (GT genotype, OR = 12.250; CI: 9.720-84.383, p < 0.001) polymorphisms were strongly associated with insulin resistance. CONCLUSION: Our study supports that FTO gene rs9939609 and rs17817449 polymorphisms are associated with insulin resistance independently of age, gender, and BMI.