METHOTREXATE-RELATED OSTEOPATHY AS AN OVERLOOKED COMPLICATION: A CASE SERIES

OpenAlex İngilizce

Low dose methotrexate (MTX) still remains as the cornerstone in the treatment of rheumatic diseases such as rheumatoid arthritis (RA) and psoriatic arthritis. Clinicians have been aware of common side effects of MTX for over five decades, whereas there have been rarely seen and relatively easily overlooked complications that had been reported to be associated with MTX in the literature, such as MTX osteopathy. The use of high doses of MTX has been demonstrated to have negative effects on bone formation and bone mineral density as well as long-term low dose, which is relatively less common. Diagnosis of MTX osteopathy might be challenging as there is no specific clinical features. Herein, we present 3 patients with RA diagnosis who developed MTX osteopathy during follow-ups.