Makale detayı · 2008
Mutations in STAT3 and IL12RB1 impair the development of human IL-17\u2013producing T cells
- Yıl
- 2008
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Experimental Medicine
- Katalog eşleşmesi (ISSN) Journal of Experimental Medicine
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
The cytokines controlling the development of human interleukin (IL) 17--producing T helper cells in vitro have been difficult to identify. We addressed the question of the development of human IL-17--producing T helper cells in vivo by quantifying the production and secretion of IL-17 by fresh T cells ex vivo, and by T cell blasts expanded in vitro from patients with particular genetic traits affecting transforming growth factor (TGF) beta, IL-1, IL-6, or IL-23 responses. Activating mutations in TGFB1, TGFBR1, and TGFBR2 (Camurati-Engelmann disease and Marfan-like syndromes) and loss-of-function mutations in IRAK4 and MYD88 (Mendelian predisposition to pyogenic bacterial infections) had no detectable impact. In contrast, dominant-negative mutations in STAT3 (autosomal-dominant hyperimmunoglobulin E syndrome) and, to a lesser extent, null mutations in IL12B and IL12RB1 (Mendelian susceptibility to mycobacterial diseases) impaired the development of IL-17--producing T cells. These data suggest that IL-12Rbeta1- and STAT-3--dependent signals play a key role in the differentiation and/or expansion of human IL-17-producing T cell populations in vivo.
Konular
Atıflar
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436 atıf
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Yerel katalogda bu makaleye atıf yapan 42 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Revisiting Human IL-12Rβ1 Deficiency 2010
- Determination of cut-off titers and agreement between immunofluorescence and immunoblotting methods for detecting antinuclear antibodies in children 2010
- Revisiting Human IL 12R 1 Deficiency 2010
- Revisiting Human IL-12Rβ1 Deficiency 2010
- Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant 2018
- Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common iTYK2/i missense variant/title 2018
- Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common iTYK2/i missense variant/title 2018
- Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23 2018
- A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity 2018