Makale detayı · 2023
Effect of exogenous Melatonin administration on Spermatogenesis in chronic unpredictable stress rat model
- Yıl
- 2023
- ISSN
0798-2259- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
This study investigated the hormonal, inflammatory, oxidant–antioxidant, and histopathological effects of exogenous Melatonin administration on Spermatogenesis in rats' chronic unpredictable stress model (CUSM). In the study, stress caused a decrease in follicle stimulating–hormone (FSH), luteinizing hormone (LH), Testosterone, Melatonin, Glutathione (GSH), Glutathione peroxidase (GSH–Px), catalase, interleukin 10 (IL–10) levels and motility, and an increase in Corticosterone, nuclear factor kappa beta (NF–kB), tumor necrosis factor–alpha (TNF–α), interleukin 1 beta (IL–1β), interleukin 6 (IL–6), abnormal sperm, dead/live sperm ratio and exogenous Melatonin reduced inflammatory cytokines and oxidative stress and improved spermatological parameters (P<0.05). Melatonin also partially corrected stress–induced changes in testicular morphology. As a result, using Melatonin in rats with CUSM may be effective in improving spermatological parameters through anti–inflammatory and antioxidant mechanisms.
Konular
- Sperm and Testicular Function
- Circadian rhythm and melatonin
- Birth, Development, and Health
Birincil konu Sperm and Testicular Function