Makale detayı · 2016 · article
Synthesis and evaluation of naphthalene based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
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- YÖKSİSYÖKSİS makale kaydı
- YÖKSİS dergi adıJournal of Enzyme Inhibition and Medicinal Chemistry
- Katalog eşleşmesi (ISSN)Journal of Enzyme Inhibition and Medicinal Chemistry
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Özet
Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory effect on LNCaP cells. Among these compounds, 4-(naphthalen-1-yl)-1-[1-(4-hydroxyphenyl)ethylidene)thiosemicarbazide (6), which caused more than 50% death on LNCaP cells, was chosen for flow cytometric analysis of apoptosis. Flow cytometric analysis pointed out that compound 6 also showed apoptotic effect on LNCaP cells. Compound 6 can be considered as a promising anticancer agent against LNCaP cells owing to its potent cytotoxic activity and apoptotic effect.
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Yerel katalogda bu makaleye atıf yapan 11 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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