Relationship of Pentraxin-3 and Suppression of Tumourigenicity 2 with Myocardial Injury in Non-Cardiac Surgery

OpenAlex İngilizce

Introduction: Myocardial injury after non-cardiac surgery (MINS) is a prevalent complication.It is caused by both cardiac and noncardiac pathophysiological mechanisms.Previous studies have identified pentraxin-3 (PTX-3) and suppression of tumourigenicity 2 (ST2) as potential biomarkers associated with myocardial injury.This study is designed to evaluate the role of PTX-3 and ST2 in predicting early MINS.Methods: This prospective observational cohort study involved patients who were deemed to be at moderate to high-risk of undergoing non-cardiac surgery.In patients with normal preoperative hs-cTnT levels, MINS was defined as a pattern of increase and/ or decrease, in high-sensitivity cardiac troponin T (hs-cTnT) levels at 24 and 72 hours postoperatively.Patients without a significant change in hs-cTnT levels pre-and postoperatively were considered MINS-negative.Preoperative PTX-3 and ST2 biomarker levels were compared between MINS-positive and MINS-negative groups.Results: The study population comprised 340 patients, of whom 79 (23.24%) were classified as MINS-positive and 261 (76.76%) as MINS-negative.PTX-3 levels were significantly higher in the MINS-positive group than in the MINS-negative group (0.24±0.11 vs. 0.021±0.06,p=0.007).There was no significant difference in the level of ST2 between the two groups of patients.Conclusion: Elevated PTX-3 levels in the MINS-positive group suggest that this biomarker may serve as a valuable predictor of myocardial injury.