Diyabete Bağlı Kognitif Bozukluk Sıçanların Hipokampüslerinde Nlrp3 ve Nitrotirozin Seviyelerinin Artışı ile İlişkilidir

Türkçe

Aim: Diabets mellitus is associated with impaired learning and memory.Neuroinflammation is a pathophysiological hallmark of diabetes which include production of cytokines.It was suggested that nitrative injury has been implicated in the pathophysiologic mechanism of diabetes.Nod-like receptor family pyrin domain-containing (NLRP) inflammasomes are important in the development of inflammatory response through production of IL-1β and IL-18.In the present study was aimed to examine the relationship between NLRP3, IL-1 β, nitrotyrosine levels and cognitive functions in diabetic rats. Material and Methods:The rats were randomly divided into 2 groups: control and diabetic.Diabetes was induced by a single intraperitoneal injection of 60 mg/kg of streptozotocin (STZ).Body weight and blood glucose level were measured until euthanasia.Morris water maze (MWM) was used to evaluate the cognitive function in rats.Hippocampal NLRP3, IL-1 β and nitrotyrosine levels were measured. Diabetes Incuced Cognitive Impairment isAssociated with Increase of NLRP3 and Nitrotyrosine Levels in the Hippocampus of Rats Diyabete Bağlı Kognitif Bozukluk Sıçanların Hipokampüslerinde NLRP3 ve Nitrotirozin Seviyelerinin Artışı ile İlişkilidir Bu makaleye yapılacak atıf: Onar B, Sayan Özaçmak H, Turan İ, Özaçmak VH.Diyabete Bağlı Kognitif Bozukluk Sıçanların Hipokampüslerinde NLRP3 ve Nitrotirozin Seviyelerinin Artışı ile İlişkilidir.