Too Rare Association; Fundal Diverticulum And Small Bowel Adenocarcinoma

İngilizce (OpenAlex)

Introduction: Vitamin B12 deficiency is essential to treat because of hematologic and neurologic results. Sublingual methylcobalamin spray leads to easy, safe, and cost-effective treatment. However, studies reveal the different duration of treatment; age-specific dose is not precise. Here, we aimed to investigate the efficacy, dose adjustment, and durability of vitamin-B12 spray. Methods: This retrospective study includes seventeen children (3 months-17 years) diagnosed with nutritional Vitamin-B12 deficiency between January 2020- January 2021. The methylcobalamin doses were 500 mcg (<1 year of age) and 1000 mcg (≥1 year of age) every day for the first week and every other day for seven weeks. In addition, serum Vitamin B12 and hemoglobin levels were studied at diagnosis and second, sixth, and twelfth months of treatment. Finally, we compared the beginning hemoglobin and Vitamin-B12 levels with the second month's values. Results: After two months of sublingual methylcobalamin treatment, the Vitamin B12 significantly increased (p=0.008) and kept normal ranges for twelve months. Hemoglobin levels tended to rise in two months, but the difference was not statistically significant (p=0.22). Conclusion: There is no consensus on the sublingual methylcobalamin dose and treatment schedule. However, we suggest that a 500 mcg dose of methylcobalamin for <1 year of age and a 1000 mcg dose for ≥ 1 year with two months treatment period is appropriate and safe for nutritional Vitamin B12 deficiency.