Relationships Between Glycemic Control and Platelet Indices, Atherogenic Index of Plasma and Vitamin D in Patients with Type 2 Diabetes

OpenAlex İngilizce

Objectives: Vitamin D deficiency, increased platelet indices and abnormal lipid profile are closely associated with increased vascular complications in type 2 diabetes mellitus (T2DM) patients.We investigated the relationship between glycemic control and platelet indices, vitamin D, atherogenic index of plasma (AIP) and other lipid components in T2DM patients. Materials and Methods:Diabetic subjects were divided into the groups 1 (good glycemic control, n=59 patients), 2 (moderate glycemic control, n=71 patients), and 3 (poor glycemic control, n=95 patients) according to the HbA1c levels of <7%, 7-9%, and >9%, respectively.We retrospectively analyzed serum lipid profile, platelet count, platelet indices, calcium, phosphorus, vitamin D and HbA1c levels in all patients.The AIP values of the subjects were calculated as follows: AIP=[log triglyceride/high density lipoprotein cholesterol (HDLc)]. Results:In group 1, the mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), triglyceride and AIP levels were lower, and the HDLc levels were higher than in group 3. Platelet indices, lipid profile, and AIP values of group 2 did not differ from those of group 1 or group 3.There was no difference among the three groups in terms of vitamin D levels.HBA1c levels were positively correlated with the duration of diabetes, triglycerides, AIP, PDW, MPV, and P-LCR, and negatively correlated with HDLc.Results: Increased platelet indices (MPV, PDW and P-LCR) and AIP values were observed in poor glycemic controlled diabetics.Accordingly, these parameters may be helpful in assessing increased cardiovascular risk in diabetics.