Makale detayı · 2026
Acute Effects of Capsaicin Administration on Diaphragm Muscle Contraction and the Role of the TRPV1 Receptor
Uludağ Üniversitesi Tıp Fakültesi Dergisi
- Yıl
- 2026
- ISSN
1300-414X- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
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Özet
İngilizce (OpenAlex)
Sudden Unexpected Death in Epilepsy (SUDEP) is primarily associated with respiratory failure and complete cessation of respiration caused by seizures. The aims of this study were to investigate basal contraction dynamics and calcium regulation in diaphragmatic muscles of rats with absence epilepsy induced by low-dose pentylenetetrazol (PTZ), and to investigate the dose-dependent effects of capsaicin, an activator of the TRPV1 calcium channel, on TRPV1, RyR1, cellular calcium kinetics, and mechanistic contraction properties ex vivo. Thirty-two male rats (n=8/group) were used to form four groups: Control, PTZ (25 mg/kg), PTZ + 1 μM capsaicin, and PTZ + 10 μM capsaicin. Isolated diaphragmatic muscle strips were placed in an organ bath, and isometric contraction parameters were recorded at a basal frequency of 0.2 Hz and a frequency range of 1–5 Hz. TRPV1 and RyR1 mRNA expression levels in muscle tissues were analyzed using qRT-PCR following contraction recordings. Compared to the control group, the PTZ group showed prolonged contraction and relaxation times at all stimulation frequencies, and the maximum relaxation velocity and total contractile force were significantly reduced (p
Konular
- Ion Channels and Receptors
- Ion channel regulation and function
- Pain Mechanisms and Treatments
Birincil konu Ion Channels and Receptors