Makale detayı · 2026
Anti-inflammatory and Anti-oxidant Efficacy of Origanum Species and Honey in A Rat Model of COPD
Iranian Journal of Basic Medical Sciences
- Yıl
- 2026
- ISSN
2008-3866- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Objectives: , and honey in a rat model of elastase-induced COPD. Materials and Methods: treatment, and honey treatment. COPD was induced via intratracheal porcine pancreatic elastase. Treatments were administered orally for 15 days. Serum levels of IL-1α, IL-33, and HMGB1, and lung homogenate levels of MMP-9 and TIMP-1 were measured by ELISA. T cell subtypes (CD3⁺, CD4⁺, CD8⁺) were analyzed by flow cytometry. Blood gas parameters were evaluated, and histopathological scoring was performed. Results: 0.05), and lymphoid aggregates were observed only in the COPD group. Conclusion: The findings indicate that Origanum species and honey may have therapeutic potential for COPD by modulating inflammation, the immune response, and the protease-antiprotease balance. Further molecular and clinical studies are warranted.
Konular
- Bee Products Chemical Analysis
- Synthesis and bioactivity of alkaloids
- Morinda citrifolia extract uses
Birincil konu Bee Products Chemical Analysis