Kronik Miyeloid Lösemi Tanılı ErkekHastalarda İmatinib TedavisininErektil Fonksiyonlar Üzerine EtkisininDeğerlendirilmesi

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Hastalarda İmatinib Tedavisinin Erektil Fonksiyonlar Üzerine Etkisinin DeğerlendirilmesiObjective: The significant survival and moleculer response in chronic myeloid leukemia (CML) are obtined with treatment tyrosine kinase inhibitors (TKI) especially imatinib.Its recommended that fertile woman exposured to imatinib should avoid to get pregnancy because of teratogenicity affect of TKIs.Animal studies reported that imatinib has affecting on spermatogenesis and erectil dysfunctions (ED) occered due to diabet can reduce by treatment of TKIs.In this study, we investigated affect on erectil functions of imatinib in adult males. Patients and Methods:We determined patients who had not any disease except of CML, had not used any drug except of TKI, used TKI least six months and had not history of surgery in the last six months among CML patients.The type of TKI, dosages and duration time of drug were assigned.Erectil functions were evaluated by using the International Index of Erectil Function (IIEF-5).Results: We achieved 31 cases appropriated include criterias.Twelve (38.7%) of cases had no ED.In 24 cases treated with imatinib, 10 (41.5%) of cases had no ED, in contrast of 11 (45.8%) of cases Evaluation of Affect on Erectil Functions of Imatinib in Male Patients with Chronic Myeloid Leukemia