Synthesis, Structural Characterization, and Biological Evaluation of Some Hydrazone Compounds as Potential Antioxidant Agents

İngilizce (OpenAlex)

Abstract Antioxidants are sufficiently stable molecules that neutralize free radicals by electron transfer and thereby reduce their damaging capacity. Hydrazones, which are frequently used in the discovery studies of new antioxidant agents, are bioactive compounds with very significant utilization areas because of their various biological and clinical applications. In this study, in vitro antioxidant activities of the previously synthesized hydrazone compounds against various free radicals were examined, one by one. It was determined that among the synthesized compounds (II–VIII), especially the compound (II) had a significant effect (IC50 = 4.4 ± 0.04 µg/mL for DPPH, IC50 = 1.8 ± 0.07 µg/mL for ABTS and A0.5 = 2.2 ± 0.02 µg/mL for CUPRAC) on the prevention of free radical-induced oxidative stress, as better results were obtained than the standard substance. All synthesized compounds showed good antioxidant effects compared to BHA in the CUPRAC method. The obtained results demonstrate that most of the synthesized molecules are promising antioxidant agents.