Makale detayı · 2019
Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study
- Yıl
- 2019
- ISSN
0735-7907- Tür
- article
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Özet
İngilizce (OpenAlex)
Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells.
Konular
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
Birincil konu Ion channel regulation and function