CCAAT Enhancer-binding Protein Alpha (CEBPA) Gene Expression in a Cohort of Turkish Patients with Multiple Myeloma

OpenAlex İngilizce

Hematopoiesis is regulated and maintained by the function of the particular transcription factors.CCAAT enhancer-binding protein alpha (CEBPA), an important transcription factor, has a part in the regulation of cell cycle, granulocytic differentiation, and more.The possible role of CEBPA in multiple myeloma (MM) development has not been clarified so far.Therefore, this study aimed to explore the relationship between the expression levels of the CEBPA gene in Turkish patients diagnosed with MM. METHODSUsing quantitative real-time PCR, the expression level of the CEBPA gene was examined in the bone marrow samples of 44 MM patients and 13 healthy controls.Statistical analyses were performed using SPSS, 13.3.1,and p<0.05 was evaluated as statistical significance level. RESULTSAlthough there was a decrease CEBPA expression levels in the patient group compared to the control group, no statistically significant relationship was found in terms of CEBPA gene expression level and MM compared with the controls (p=0.436). CONCLUSIONOur findings suggest that the change in the expression level of CEBPA transcript itself has probably no effect in the pathogenesis of MM patients, although it is an important problem that needs further researches with large-scale samples.