Makale detayı · 2018
A novel strategy for cartilage tissue engineering: Collagenase-loaded cryogel scaffolds in a sheep model
International Journal of Polymeric Materials and Polymeric Biomaterials
- Yıl
- 2018
- ISSN
0091-4037- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
In this study, we developed a novel strategy, through which cartilage tissue pieces were placed in a sheep cartilage defect model and covered with a collagenase incorporated cryogel scaffold (in vivo cartilage tissue engineering, IVCTE group). While applying this strategy, the chondrocytes could be isolated inside the body and the treatment could be accomplished in one session. To compare our strategy, to another group, in which we used cultured cells and Chondro-gide, standard matrix-induced autologous chondrocyte implantation (MACI) was applied. Although the MACI applied group demonstrated better healing than IVCTE, the type II collagen synthesis was better in the IVCTE group compared to MACI applied group. Collagenase did not have detrimental effect on surrounding cartilage in IVCTE group. The preliminary results of the novel strategy applied group (IVCTE) were promising.
Konular
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
Birincil konu Osteoarthritis Treatment and Mechanisms