Does 75-g OGTT Influence Maternal and Fetal Doppler Parameters in Healthy Pregnancies? A Cross-Sectional Observational Study

İngilizce (OpenAlex)

Aim: Oral glucose challenge test (OGTT) is widely used around the world screening for gestational diabetes mellitus (GDM). In our study, we aimed to evaluate the effect of 75 g OGTT on maternal and fetal Doppler parameters. Material and Methods: Measurements of umbilical artery PI, RI, S/D, middle cerebral artery (MCA) PSV, PI, RI and mean PI, RI S/D of uterine arteries assessed 1 hour before OGTT and 1 hour following the test in 46 pregnancies between 24-28 weeks of gestation. Mann Whitney-U test was employed to compare variables. Statistical significance was established at p<0.05. Results: The mean age of pregnant women was 24.6±5.4, the mean gravity status was 2.3±0.8, the mean BMI was 25.5±5.5 kg/m, and the mean gestational age was 26.5±1.6 Mean umbilical artery PI: 1.14±0.26, RI: 0.71±0.14, S/D ratio 2.24±0.73 calculated 1 hour before test and mean PI: 1.04±0.43, RI: 0.58±0.21, S/D ratio 2.01±0.44 and there was no significance (p: 0.64, 0,56, 0.71). Mean MCA PSV: 30.4±11.3 cm/sn, PI:1.89±0.36, RI: 0.81±0.19 measured 1 hour before test and 1 hour following test Mean MCA were PSV: 38.4±13.2 cm/sn, PI: 2.11±0.24, RI: 0.68± 0.21 and there was no difference (p: 0.83, 0.66, 0.82). Mean uterine arteries PI:1.13±0.21, RI: 0.69±0.11, S/D ratio 2.03±0.34 measured before the test and mean PI:1.24±0.11, RI: 0.74±0.16, S/D ratio 1.87±0.22 calculated after the test and these results were similar (p: 0.72, 0.79, 0.56). Conclusion: There was no significant effect on maternal and fetal Doppler parameters of 75 g OGTT among healthy pregnancies.