Makale detayı · 2022
Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity
Dergi
Chemistry & BiodiversityISSN 1612-1872
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- Yıl
- 2022
- Tür
- article
Veri kaynağı ayrımı
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- YÖKSİS dergi adı Chemistry & Biodiversity
- Katalog eşleşmesi (ISSN) Chemistry and Biodiversity
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Özet
OpenAlex · İngilizce
Abstract In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe3+ and Cu2+ reductive ability and Fe2+ chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCA I and hCA II), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and α‐glycosidase (α‐gly). Ki values were found these compounds in range of 0.24±0.05–1.38±0.34 μM against hCA I, 0.194±0.018–1.03±0.06 μM against hCA II, 0.043±0.01–0.154±0.02 μM against AChE, 3.92±1.08–11.93±4.45 μM against BChE, 0.082±0.0008–1.68±0.42 μM against AR, and 6.93±2.74–17.17±6.70 μM against α‐glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.
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Yerel katalogda bu makaleye atıf yapan 92 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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