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Makale detayı · 2018

Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study

CRITICAL CARE

YÖKSİS OpenAlex Açık erişim · gold SJR Q1 JCR Q1 Atıf 129 Üst %10 Yüzdelik 98.6% FWCI 8.95
Yıl
2018
ISSN
1466-609X
DOI
10.1186/s13054-018-2013-1
Tür
article

Veri kaynağı ayrımı

  • YÖKSİS YÖKSİS makale kaydı
  • OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)

OpenAlex kaydı

Özet

İngilizce (OpenAlex)

BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included. The presence of systemic inflammatory response syndrome (SIRS), severe sepsis, and septic shock were assessed and documented based on the consensus criteria of the American College of Chest Physicians and Society of Critical Care Medicine (SEPSIS-I) in infected patients. Patients with septic shock were also assessed using the SEPSIS-III definitions. Data regarding demographics, illness severity, comorbidities, microbiology, therapies, length of stay, and outcomes (dead/alive during 30 days) were recorded. RESULTS: Of the 1499 patients included in the analysis, 237 (15.8%) had infection without SIRS, 163 (10.8%) had infection with SIRS, 260 (17.3%) had severe sepsis without shock, and 203 (13.5%) had septic shock. The mortality rates were higher in patients with severe sepsis (55.7%) and septic shock (70.4%) than those with infection alone (24.8%) and infection + SIRS (31.2%) (p < 0.001). According to SEPSIS-III, 104 (6.9%) patients had septic shock (mortality rate, 75.9%). The respiratory system (71.6%) was the most common site of infection, and Acinetobacter spp. (33.7%) were the most common isolated pathogen. Approximately, 74.9%, 39.1%, and 26.5% of Acinetobacter, Klebsiella, and Pseudomonas spp. isolates, respectively, were carbapenem-resistant, which was not associated with a higher mortality risk. Age, acute physiology and chronic health evaluation II score at ICU admission, sequential organ failure assessment score on study day, solid organ malignancy, presence of severe sepsis or shock, Candida spp. infection, renal replacement treatment, and a nurse-to-patient ratio of 1:4 (compared with a nurse-to-patient ratio of 1:2) were independent predictors of mortality in infected patients. CONCLUSIONS: A high prevalence of sepsis and an unacceptably high mortality rate were observed in Turkish ICUs. Although the prevalence of carbapenem resistance was high in Turkish ICUs, it was not associated with a higher risk for mortality. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT03249246 . Date: August 15, 2017. Retrospectively registered.

Konular

  • Sepsis Diagnosis and Treatment
  • Nosocomial Infections in ICU
  • Intensive Care Unit Cognitive Disorders

Birincil konu Sepsis Diagnosis and Treatment

Yazarlar

  1. ZEHRA NUR BAYKARA
  2. EMİN HALİS AKALIN
  3. MUSTAFA KEMAL ARSLANTAŞ
  4. VOLKAN HANCI
  5. ÇİĞDEM ÇAĞLAYAN
  6. FERDA ŞÖHRET KAHVECİ
  7. KUBİLAY DEMİRAĞ
  8. CANAN BAYDEMİR
  9. MUSTAFA NECMETTİN ÜNAL
  10. Pınar Özdemir
  11. HÜLYA ULUSOY
  12. DİLEK MEMİŞ TRAKYA ÜNİVERSİTESİ
  13. MAKBULE CAVİDAN ARAR TEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİ
  14. Elif Yılmaz
  15. MELEK GÜRA ÇELİK
  16. İSMAİL HAKKI CİNEL
  17. SİBEL TEMÜR
  18. MEHMET AKİF YAŞAR
  19. Hamdiye Çulha
  20. Canan Balcı
  21. Sultan San
  22. Asena Salbes
  23. Elçin Özkan
  24. Onur Palabıyık
  25. JALE BENGİ ÇELİK
  26. ALPER YOSUNKAYA NECMETTİN ERBAKAN ÜNİVERSİTESİ
  27. Faruk Çiçekçi
  28. IŞIL ÖZKOÇAK TURAN
  29. İsmail Katı
  30. HÜLYA BAŞAR
  31. Sema Turan
  32. SÜHEYLA ÜNVER
  33. Ünase Büyükkoçak
  34. Aynur Akın
  35. Sinan Gürsoy
  36. AYNUR KARAYOL AKIN
  37. Demet Tok
  38. Simay Serin
  39. Sema Dursun Kıter
  40. Hakan Doğan
  41. Abdulkadir Oruç
  42. ONUR BALABAN
  43. Demet Tüfek
  44. İBRAHİM KURT
  45. Murat Bilgi
  46. Verda Tuna
  47. Ayşegül Özkök
  48. Ahmet Şen
  49. Nilay Taş
  50. HİLAL AYOĞLU
  51. BERNA KAYA UĞUR
  52. Sedat Kaya
  53. Mustafa Kahraman
  54. Zahide Doğanay
  55. Gökalp Soykam
  56. Işıl Köse
  57. BİRGÜL YELKEN ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ
  58. GÖNÜL ÖLMEZ KAVAK
  59. Uğur Göktaş
  60. Türkan Togal
  61. Nazım Doğan
  62. Murat Gündüz
  63. SELİM TURHANOĞLU
  64. ATİLLA RAMAZANOĞLU
  65. Füsun Eroğlu
  66. Şaban Yalçın
  67. Hatice Yağmurdur
  68. ATİLLA TUTAK
  69. ALİ AYDIN ALTUNKAN
  70. UFUK KUYRUKLUYILDIZ
  71. Gülsüm Oya Hergünsel
  72. Kerem Erkalp
  73. ALİ NECATİ GÖKMEN DOKUZ EYLÜL ÜNİVERSİTESİ
  74. MURAT AKSUN
  75. HALİL ERKAN SAYAN
  76. ONUR ÖZLÜ
  77. YAVUZ DEMİRARAN DÜZCE ÜNİVERSİTESİ
  78. EVREN ŞENTÜRK
  79. IŞIN GENÇAY
  80. Hafize Öksüz
  81. Nihan Yapıcı
  82. Araş Pirat
  83. Tuğhan Utku
  84. ENDER GEDİK
  85. Orhan Behret
  86. Kadir İdin
  87. Hayrettin Daşkaya
  88. Filiz Banu Etemoğlu
  89. Ali Alagöz
  90. SEVAL İZDEŞ
  91. MUSTAFA KEMAL BAYAR
  92. NERMİN KELEBEK GİRGİN
  93. LALE KARABIYIK
  94. Uğur Koca
  95. Nurcan Çubukçu
  96. Fatma Ülger
  97. ŞEYDA EFSUN ÖZGÜNAY
  98. Perihan Ergin Özcan
  99. BAŞAR ERDİVANLI
  100. Şenay göksu Tomruk
  101. Abbas Köse
  102. Rafi Doğan
  103. Güldem Turan
  104. Osman Arpaz
  105. Aliye Esmaoğlu
  106. Musa Salmanoğlu
  107. Özgür Canoler
  108. NEDİM ÇEKMEN
  109. Canan Kandaz
  110. Gülşen Bulut Kaya
  111. Melis Türker
  112. İlknur Şeker
  113. Aysu Hayriye Tezcan
  114. Halil İbrahim Uzunlar
  115. Mehmet Akif Yazar
  116. Reyhan Arslantaş
  117. Okay Öztürk
  118. Zakir Arslan
  119. Özgür Özmen
  120. GÜNSELİ ORHUN
  121. Evren Büyükfırat
  122. Oya Çimen Budur
  123. Mehmet Erdem Akçay
  124. Asu Özgültekin
  125. Ertuğrul Kılıç
  126. Makbule Elif Yılmaz
  127. Ömür İlban
  128. Feyza Kargın
  129. Resul Altuntaş
  130. MEHMET MURAT SAYIN
  131. OSMAN EKİNCİ
  132. Berna Çalışkan
  133. Ayşen Erdoğan
  134. Volkan Alparslan
  135. Murat Tekin