Makale detayı · 2024
Safety Evaluation and Tolerability Overview of Favipiravir in the Management of COVID-19: A Real-Life Experience from Turkey
Istanbul Medical Journal
- Yıl
- 2024
- ISSN
2619-9793- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Introduction: Coronavirus diseases-2019 (COVID-19) have been ongoing for more than two years.Despite the scientific research conducted in this process, there is still no widely accepted definitive treatment for the disease.For treating COVID-19, using antiviral agents previously used for the treatment of other RNA-virus infections has been seen as a fast way to a solution, and favipiravir is one of the leading agents.This prospective, multicenter, observational study was designed to investigate the safety of favipiravir in 500 patients treated with favipravir for favipravir.Methods: This study was conducted as a multicenter prospective study.Eight different sites from four cities participated, and 500 patients were included in the study.Follow-up of laboratory parameters, adverse events (AEs), and amelioration of fever, dyspnea, and cough symptoms of the patients was recorded in a case report form.Results: A total of 475 patients from eight centers completed the study.A total of 401 AEs were reported in 206 (51.4%) patients, which were mild-to-moderate in the majority of cases.Serious AEs occurred in 5 patients and death occurred in 4 patients.From the first to the last measurement, serum alanine aminotransferase levels (31.9±27.7 vs. 47.2±49.7 U/L, p<0.001) increased, whereas C-reactive protein (39.9±66.4 vs. 15.2±30.5 mg/L, p<0.001) and creatine kinase (101.7±187.7 vs. 71.9±43.5 U/L, p=0.018) levels decreased.In follow-up parameters, oxygen saturation (SpO 2 ; 96.2±2.7 vs. 97.5±2.1%,p<0.001) and amelioration of fever (>37.8 for 6.6% on day 3, 3.2% on day 5, and 0.6% on day 10), dyspnea (for 56.4% on day 5, 62.4% on day 7, and 81.2% on day 10), and cough (46.0% on day 5, 73.0% on day 7, and 87.3% on day 10) were noted in an increasingly higher percentage of patients with continued therapy.Conclusion: The current study provides real-life data of favipiravir, which is a unique option in Turkey for treating COVID-19 patients.The results revealed that favipiravir is a well-tolerated agent with a low side-effect profile.However, it needs to be evaluated with well-designed, dose-compared, randomized controlled studies for the evaluation of efficacy.
Konular
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
Birincil konu COVID-19 Clinical Research Studies