Makale detayı · 2024
Dimethyl Fumarate Improves Detrusor Contractility in Streptozotocin-Induced Diabetic Rats
Turkish Journal of Diabetes and Obesity
- Yıl
- 2024
- ISSN
2587-0335- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
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Özet
İngilizce (OpenAlex)
Aim: The present study aimed to investigate potential effect of dimethyl fumarate (DMF) on bladder dysfunction in streptozotocin (STZ)-induced diabetic rats. Material and Methods: Adult male Sprague Dawley rats were given a single intraperitoneal dose of streptozotocin (60 mg/kg) to induce diabetes. After eight weeks, diabetic and nondiabetic rats were orally treated with DMF (25 or 100 mg/kg/day) or vehicle for four weeks orally. At 12 week after diabetes induction, in vitro organ bath studies were performed on detrusor strips of each rat and the contractile responses to KCl and carbachol (CCh) of the strips were evaluated. Results: The maximal KCl (80 mM)- and CCh-induced contractile responses of detrusor strips significantly (p
Konular
- Hormonal Regulation and Hypertension
- Aldose Reductase and Taurine
- Nitric Oxide and Endothelin Effects
Birincil konu Hormonal Regulation and Hypertension