Makale detayı · 2022 · article
Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study
Veri kaynağı ayrımı
- YÖKSİSYÖKSİS makale kaydı
- YÖKSİS dergi adıRUSSIAN JOURNAL OF GENERAL CHEMISTRY
- Katalog eşleşmesi (ISSN)Russian Journal of General Chemistry
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- Semantic Scholaratıf sayısı (OpenAlex ile birleştirilmez)
Özet
Abstract New series of biscarbazole derivatives containing imine-amine groups was synthesized. Antimicrobial activity of newly synthesized compounds against bacterial strains and yeast isolates was determined. The effects of the synthesized test compounds on cell proliferation and NCI-60 survival parameter values were measured. In addition, in silico analysis against five different receptors with synthesized two compounds was carried out to see the necessary interactions responsible for anti-bacterial activity. The docking results of both compounds supported the antibacterial activity exhibiting high inhibition constants.
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