Makale detayı · 2025
Involvement of PERK and ATF6 signal pathways in indicating unfolded protein response in patients with chronic lymphocytic leukaemia
- Yıl
- 2025
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Biomarkers
- Katalog eşleşmesi (ISSN) Biomarkers
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
INTRODUCTION: PERK, ATF6, and IRE1α signalling pathways are unfolded protein response (UPR) signalling pathways. In this study, we evaluated the effect of PERK and ATF6 signalling pathways, in chronic lymphocytic leukaemia (CLL) patients. METHODS: ELISA was performed on peripheral blood plasma samples from the CLL group and the control group for the markers eIF2AK3, GRP78, ATF6, CHOP, HIF-1α and caspase 3. RESULTS: In this study, the levels of eIF2AK3, GRP78, ATF6 and CHOP were higher in the CLL group than in the control group (p = <0.001, p = <0.001, p = <0.001, p = <0.001, respectively). While no difference was observed between the CLL group and the control group in terms of HIF-1α level, caspase 3 level was higher in the CLL group (p = <0.001). There was a positive relationship between the level of HIF-1α and the levels of ATF6 and CHOP (r = 0.648, p = <0.001; r = 0.727, p = <0.001, respectively). Also, a positive correlation was observed between caspase 3 level and ATF6 level (r = 0.301, p = 0.030). DISCUSSION: In this study, markers associated with PERK and ATF6 signalling pathways were higher in CLL patients.
Konular
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Autophagy in Disease and Therapy
Birincil konu Endoplasmic Reticulum Stress and Disease