Makale detayı · 2025
Plasma miRNA Profiles in Chronically Treated Bipolar Disorder Patients: A Case–Control Study
Clinical Psychopharmacology and Neuroscience
- Yıl
- 2025
- ISSN
1738-1088- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Objective: This study aimed to determine the molecular repercussions of chronic treatment and potential biomarker candidates by comparing the expression profiles of 34 selected miRNAs in peripheral plasma of patients with bipolar disorder receiving pharmacotherapy for at least one year with healthy controls. Methods: IFC platform. Control and bipolar groups were compared based on ΔCt values. Results: values less than 0.05, but they lost statistical significance after false discovery rate correction. Conclusion: Peripheral plasma miRNA profiles in chronic bipolar disorder revealed elevated miR-92a-3p and miR-486-5p and decreased miR-222-3p, miR-574-3p, miR-145-5p and miR-195-5p. These miRNAs may be suitable for evaluation as minimally invasive biomarker candidates in bipolar disorder, and their potential clinical use in diagnosis, prognosis, and treatment monitoring should be investigated with further studies.
Konular
- Bipolar Disorder and Treatment
- MicroRNA in disease regulation
- Phosphodiesterase function and regulation
Birincil konu Bipolar Disorder and Treatment