Pulse Wave Analysis in Obese Children with and without Metabolic Syndrome

İngilizce (OpenAlex)

What is already known on this topic?In the latest arterial HT guidelines published for adult patients, PWA is recommended because of its high predictability, easy applicability, and reproducibility in determining cardiovascular risk.Study on pulse wave velocity in children and adolescents with metabolic syndrome is limited. What this study adds?This study showed that additional risk factors other than obesity, which are required for the diagnosis of MS, further increase 24-hour and daytime cSBP and cDBP.Therefore, PWA analysis is needed to better determine cardiovascular risk and target organ damage in children with MS. ABSTRACT Objective:We aimed to compare the pulse wave analysis (PWA) of obese children with and without metabolic syndrome (MS) with healthy non-obese children and to evaluate the reflections of additional risk factors that children with MS have in addition to obesity on PWA.Methods: Among all obese patients examined between June 2019 and June 2021, 41 patients with MS, 36 obese patients without MS, and 34 healthy non-obese children of similar age and gender were evaluated retrospectively.Anthropometric measurements, biochemical evaluations, 24-hour ambulatory blood pressure measurement (ABPM), left ventricular mass index (LVMI) and PWA measurements were compared.Results: When the three groups were compared, weight SDS, height SDS and BMI SDS; It was found to be significantly higher in the MS group (p<0.05).In ABPM measurements, the systolic and MAP blood pressure (BP) SDSs load; in PWA, night central systolic BP, 24-hour, day and night pulse pressure values and 24-hour, day and night pulse wave velocity (PWV) rates; in cardiac evaluations, LVMI and relative wall thickness measurements were significantly higher in MS and non-MS obese patients compared to the control group (p<0.05).24-hour and daytime central systolic and diastolic BP values were significantly different in 3 groups, the highest in MS patients (p<0.05).Conclusion: Obesity causes higher office, ambulatory and central BP, PWV and LVMI, however additional risk factors leading to MS do not contribute to these parameters except for 24-hour and daytime cSBP and cDBP values.