After methimazole dose escalation developing agranulocytosis in long-term use of methimazole

İngilizce (OpenAlex)

Objective:The purpose of this study is to examine the protective effects of maresin 1 on testicular injury induced by ischemia reperfusion.Methods: 24 Sprague-Dawley male rats were divided into 3 groups.The groups are planned as follows; sham, ischemia reperfusion and ischemia reperfusion+maresin 1 groups.The spermatic cord was detected and clamped for 2 hours to establish the prompt.After 2 hours, the clamp was removed and testicular reperfusion was achieved for 2 hours.At the end of the reperfusion phase, testicular tissues were taken and total antioxidant capacity (TAC), total oxidant capacity (TOC), superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO) levels were determined by spectrophotometric method.Results: In the ischemia-reperfusion group, TOS and MDA and MPO are increased, the levels of TAS and SOD molecules are decreased.TOS and SOD levels are increased and TAS, MDA and MPO levels are decreased in the Maresin-1 treatment group. Conclusion:These results show us that a single dose of maresin-1 application is effective against oxidative damage caused by ischemia reperfusion.