Makale detayı · 2020
Prognostic Significance of Glutathione Peroxidase (GSH-Px) Levels in Lumbar Degenerative Disc Disease
- Yıl
- 2020
- ISSN
2667-5846- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
Türkçe
Objective: In this study, the main aim was to research whether decreased antioxidant activity was manifesting the intervertebral disc degeneration in a population in which the degeneration could be compatible with their ages. Material and Method: The study group consisted of 39 patients with lumbar disc degeneration (LDD) and 37 healthy controls. Patient data including age, symptoms, neurological examination findings, lumbar MRI findings, Oswestry Disability Index (ODI) scores, and Visual Analogue Scale of pain (VAS) were used. Human Glutathione peroxidase (GSH-Px) level was determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: Serum GSH-Px levels were significantly lower in the patients with LDD when compared to the healthy controls (p=0.011). Conclusions: In the present study, we demonstrated that, in addition to environmental factors, there is a correlation between GSHPx enzyme deficiency and lumbar disc degeneration.
Konular
- Healthcare and Venom Research
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
Birincil konu Healthcare and Venom Research