Makale detayı · 2009
Loss of cryptochrome reduces cancer risk in p53 mutant mice
Dergi
Proceedings of the National Academy of SciencesISSN 0027-8424
ISSN kaydı başka bir dergiye işaret ediyor; ad YÖKSİS kaydından.
- Yıl
- 2009
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Proceedings of the National Academy of Sciences
- Katalog eşleşmesi (ISSN) Proceedings of the National Academy of Sciences of the United States of America
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
It is commonly thought that disruption of the circadian clock increases the cancer incidence in humans and mice. However, it was found that disruption of the clock by the Cryptochrome (Cry) mutation in mice did not increase cancer rate in the mutant mice even after exposing the animals to ionizing radiation. Therefore, in this study we tested the effect of the Cry mutation on carcinogenesis in a mouse strain prone to cancer because of a p53 mutation, with the expectation that clock disruption in this sensitized background would further increase cancer risk. Paradoxically, we find that the Cry mutation protects p53 mutant mice from the early onset of cancer and extends their median lifespan approximately 50%, in part by sensitizing p53 mutant cells to apoptosis in response to genotoxic stress. These results suggest alternative therapeutic approaches in management of cancers associated with a p53 mutation.
Konular
Atıflar
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185 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 19 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Circadian clock control of the cellular response to DNA damage 2010
- Circadian Clock Cancer and Chemotherapy 2015
- Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1 2018
- Effect of circadian clock mutations on DNA damage response in mammalian cells 2012
- DNA Damage Specific Control of Cell Death by Cryptochrome in p53 Mutant Ras Transformed Cells 2013
- Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice 2022
- Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice 2022
- Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice 2022
- Critical cholangiocarcinogenesis control by cryptochrome clock genes 2017
- Identification of two Amino Acids in the C terminal Domain of Mouse CRY2Essential for PER2 Interaction 2010