Makale detayı · 2015
Hepatoprotective effect of diffractaic acid on carbon tetrachloride induced liver damage in rats
Biotechnology & Biotechnological Equipment
- Yıl
- 2015
- ISSN
1310-2818- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
This study was designed to investigate the hepatoprotective effect of diffractaic acid isolated from a lichen species, Usnea longissima, at 3 doses, 50, 100 and 200 mg/kg, against carbon tetrachloride (CCl4)-induced hepatic damage. For this purpose, 40 Wistar albino rats were divided in 5 groups, including 3 experimental and 2 control ones, and 0.2 mL/kg of CCl4 in olive oil (1:5 v/v) was injected daily for 6 weeks intraperitoneally. After the liver injury, diffractaic acid was applied at doses of 50, 100 and 200 mg/kg for 7 days. The group given physiologic saline (0.2 mL/kg) was used as a control group. Alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, creatinine, urea, direct and total bilirubin and C-reactive protein levels were also evaluated in the serum samples obtained from the rat groups. Liver tissues were removed and were examined histopathologically following staining with hematoxylin–eosin. The results showed that 50 mg/kg daily dose of diffractaic acid could be considered to have hepatoprotective effect by ameliorating the studied biochemical parameters and tissue histological structures. However, 100 and 200 mg/kg of diffractaic acid acted as hepatotoxin and did not show any hepatoprotective effect. Thus, diffractaic acid could be potentially used as a hepatoprotective agent at a low dose (50 mg/kg) against acute liver toxicity induced by CCl4.
Konular
- Lichen and fungal ecology
- Medicinal plant effects and applications
- Plant Toxicity and Pharmacological Properties
Birincil konu Lichen and fungal ecology