A Rare Case Report: ICOS and WIPF1 Mutation Together in A Patient

OpenAlex İngilizce

The inducible T-cell costimulator (ICOS) deficiency was first described in 2003.Autosomal re-cessive inherited ICOS deficiency is classified as combined immunodeficiency (CID) and has a wide clinical spectrum including hypogammaglobulinemia, recurrent infections, enteropathies, autoimmunity, lymphoproliferation, and malignancy.WAS/WASL Interacting Protein Family Member 1 (WIPF1) mutation causes WIP deficiency, characterized by thrombocytopenia, immu-nodeficiency, and eczema.Here, we aimed to present a patient with coexisting ICOS and WIP de-ficiency.