In vitro Antimicrobial Susceptibility of Urinary Tract Infection Pathogens in Children

OpenAlex İngilizce

Aim: Urinary tract infection (UTI) is one of the most common bacterial infections in children.Empirical treatment is commenced according to the patient's characteristics and the antimicrobial susceptibility patterns in the region.Therefore, a determination of antimicrobial resistance patterns has a great importance in effective treatment.The aim of this study was to determine the pathogens which cause UTIs in patients admitted to a university hospital in Izmir and to determine their antimicrobial susceptibility pattern. Materials and Methods:The files of patients aged between 0-18 years, followed up with a diagnosis of UTI, vesicoureteral reflux and neurogenic bladder in Ege University Faculty of Medicine Paediatric Nephrology Unit between February, 2013 and November, 2018 were retrospectively reviewed.Results: A total of 1,126 positive urine cultures from 729 patients (65% female) were included in this study.Gram-negative pathogens constituted 88.2% of the cultures.Escherichia coli (E.coli) was the most commonly isolated bacteria with a prevalence of 59.1%, followed by Klebsiella pneumonia with 17.9%, and Enterococcus faecalis with 8.3% (n=93).Ampicillin, cefuroxime and trimethoprim-sulfamethoxazole with susceptibility rates of 18.6%, 39.6%, 49.0% respectively, constituted the highest resistant antimicrobials to Enterobacteriaceae.Enterococcus spp.showed the highest resistance to gentamycin with 50% resistance in tested cases.Pseudomonas spp. with 64.3% susceptibility showed the highest resistance to piperacillin-tazobactam.Conclusion: This study revealed that bacterial resistance to commonly used antimicrobials in UTI is an important and challenging problem which requires planning.