Makale detayı · 2013
Synthesis and Characterization of Celecoxib Derivatives as Possible Anti Inflammatory Analgesic Antioxidant Anticancer and Anti HCV Agents
- Yıl
- 2013
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Molecules
- Katalog eşleşmesi (ISSN) Molecules
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamides 2a-e were synthesized by the addition of ethyl a-bromoacetate and anhydrous sodium acetate in dry ethanol to N-(substituted aryl/alkylcarbamothioyl)-4-[5-(4-methylphenyl)-3-(trifluoro-methyl)-1H-pyrazol-1-yl]benzene sulfonamides 1a-e, which were synthesized by the reaction of alkyl/aryl isothiocyanates with celecoxib. The structures of the isolated products were determined by spectral methods and their anti-inflammatory, analgesic, antioxidant, anticancer and anti-HCV NS5B RNA-dependent RNA polymerase (RdRp) activities evaluated. The compounds were also tested for gastric toxicity and selected compound 1a was screened for its anticancer activity against 60 human tumor cell lines. These investigations revealed that compound 1a exhibited anti-inflammatory and analgesic activities and further did not cause tissue damage in liver, kidney, colon and brain compared to untreated controls or celecoxib. Compounds 1c and 1d displayed modest inhibition of HCV NS5B RdRp activity. In conclusion, N-(ethylcarbamothioyl)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (1a) may have the potential to be developed into a therapeutic agent.
Konular
Atıflar
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53 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 19 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-naproxen 2019
- Synthesis, molecular modeling, in vivo study and anticancer activity of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-naproxen 2019
- Synthesis of Tolmetin Hydrazide Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells 2015
- Synthesis of Tolmetin Hydrazide Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells 2015
- Synthesis of Tolmetin Hydrazide Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells 2015
- Synthesis of Tolmetin Hydrazide Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells 2015