Klinik Pseudomonas aeruginosa izolatlarının virülans özellikleri ve epidemiyolojik ilişkisi

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Pseudomonas aeruginosa is an opportunistic pathogen that can cause serious infections, especially in health care settings where host defense is impaired. In addition to resistance problem, the different virulence characteristics of these bacteria can change the course of infection and cure. In this study, it was aimed to determine antibiotic susceptibilities, epidemiological relations and virulence factors of clinical P. aeruginosa isolates. Methods: This study was performed, a total of 83 P. aeruginosa isolated from different clinical samples of Ege University Faculty of Medicine Hospital. Antibiotic susceptibilities of isolates were investigated by the VITEK 2 Compact automated system and epidemiological relations of isolates determined via "Enterobacterial Repetitive Intergenic Consensus-Polymerase Chain Reaction (ERIC-PCR)". Phenotypic tests were performed to determine the virulence factors of the selected representatives from each clone. While the "Elastin Congo Red" method was used for the investigation of elastase activity, appropriate methods applied for Protease, DNase, Lipase, Siderophore and Twitching activities to the detect virulence properties phenotypically. The biofilm production of isolates was ZET