Makale detayı · 2018
Antioxidant role of melatonin against nicotine’s teratogenic effects on embryonic bone development
Iranian Journal of Basic Medical Sciences
- Yıl
- 2018
- ISSN
2008-3866- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
OBJECTIVES: This study investigated the possible effects of low (3 mg/kg) and high (6 mg/kg) doses of nicotine on the skeletal development of rat fetuses by the double staining method and the protective role of melatonin (10 mg/kg) against these effects. MATERIALS AND METHODS: day of pregnancy. The skeletal systems of the fetuses were stained using the double staining method. The forelimbs and hindlimbs of the fetuses were firstly investigated under a stereomicroscope, and then their photos were taken. The total bone length, the length of the ossified part and the ossification rate were calculated using the ImageJ program. RESULTS: 0.05). CONCLUSION: It has been found that the use of nicotine during pregnancy delays skeletal ossification and that melatonin, a powerful antioxidant, eliminates the teratogenic effects of nicotine.
Konular
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Pregnancy and Medication Impact
Birincil konu Nicotinic Acetylcholine Receptors Study