Makale detayı · 2017
Evaluation of resveratrol organogels prepared by micro-irradiation: fibroblast proliferation through in vitro wound healing
Turkish Journal of Biochemistry
- Yıl
- 2017
- ISSN
1303-829X- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
Abstract Objective Resveratrol (RSV) has therapeutic potential with several biological activity. The aim of this study was to develop organogel formulations of RSV and to investigate the proliferation and migration via in vitro wound model of primary normal human skin fibroblasts (NHDF). Methods The optimum RSV concentration was determined by MTT assay. Three different types of polyethylene glycol (200, 400 and 600) were used to prepare Carbopol 940 based organogels by micro-irradiation method. Differential scanning microscopy (DSC) and rheological analyses were conducted. Proliferation activity and migration of fibroblast cells were determined with the Giemsa staining. Results The percentage of migration rate obtained with RSV-PEG-400 organogel was the highest, as 59.7%. The values obtained with RSV-PEG-200 and RSV-PEG-600 were 36.6% and 48.7%, respectively. Conclusion This study showed that RSV organogels produced by micro-irradiation method could be a model for active molecules that have low water solubility for different applications as pharmaceuticals, and cosmeceuticals.
Konular
- Electrospun Nanofibers in Biomedical Applications
- Food Chemistry and Fat Analysis
- Advancements in Transdermal Drug Delivery
Birincil konu Electrospun Nanofibers in Biomedical Applications