Recurrent Wheezing in Preschoolers: Association Between Peripheral Blood Cell-Derived Inflammatory Indexes and the Asthma Predictive

OpenAlex İngilizce

Objective: The current study aimed to determine the role of chronic and eosinophilic inflammation in the etiopathogenesis of recurrent wheezing in preschool children and to evaluate the relationship between these inflammatory parameters and the Modified Asthma Predictive Index (mAPI) in positive and negative groups. Materials and Methods: The study included patients under six years old who presented with recurrent wheezing complaints to pediatric immunology and allergy clinics between September 2022 and September 2023 and had not yet started asthma treatment. Demographic data such as age, gender, atopy history, and smoking exposure, along with complete blood count, total IgE levels, and aeroallergen sensitivity, were analyzed. Patients were categorized into two groups based on mAPI positivity and negativity. Results: The mAPI-positive group had significantly higher eosinophil count (p=0.004), eosinophil percentage (p=0.034), eosinophil/lymphocyte ratio (p=0.01), eosinophil/neutrophil ratio (p=0.007), and eosinophil/monocyte ratio (p