Makale detayı · 2025
Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries
Iranian Journal of Basic Medical Sciences
- Yıl
- 2025
- ISSN
2008-3874- Tür
- article
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Özet
İngilizce (OpenAlex)
Objectives: Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion (T/D) can lead to severe complications, including infertility, if not promptly addressed. This study aimed to investigate the therapeutic effects of casticin (CAST) on ovarian and lung tissue injuries induced by a bilateral ovarian T/D model in rats. Materials and Methods: Experimental animals were randomly allocated into groups of sham, T/D, CAST 5 mg/kg, and CAST 10 mg/kg. Ovarian and lung tissues were subjected to biochemical, histopathological, and immunohistochemical analyses. Results: 0.05). Conclusion: CAST demonstrated a therapeutic effect against ovarian and lung tissue damage induced by T/D, suggesting that it may serve as a potential therapeutic agent for treating ovarian T/D-related injuries. These findings underscore the potential of CAST in clinical settings, particularly as a novel intervention to mitigate complications associated with I/R injuries in gynecological emergencies.
Konular
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
Birincil konu Ovarian cancer diagnosis and treatment