Effect of aerial part and root extracts from Ferulago mughlae Peşmen and Ferulago sandrasica Peşmen and Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

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OBJECTIVES: species' extracts on the corpus cavernosum (CC). MATERIALS AND METHODS: erectile responses were obtained by stimulation of the cavernosal nerves and repeated after intracavernosal injection of extracts in rats, and the data were expressed as intracavernosal pressure (ICP)/mean arterial pressure and total ICP. The relaxant and contractile responses of CC strips were analyzed in the presence or absence of extracts. RESULTS: ) (98.30±2.6%) were decreased after incubation with L-NAME (44.8±1.8). ODQ, a soluble guanylate cyclase inhibitor, inhibited 77% of extract-induced maximum relaxation in the CC from the control rats. CONCLUSION: These species can be utilized in erectile dysfunction and may be an herbal alternative to synthetic drugs.