The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress

OpenAlex İngilizce

Purpose: This study aimed to show possible benefical effect of evodiamine against oxidative damage of intestinal tissue induced by mesenteric ischemia-reperfusion.Material and Methods: For this purpose, in our study mesenteric ischemia-reperfusion model was conducted in experimental animals. In low and high doses treatment of evodiamine and ischemia-reperfusion groups, superior mesenteric artery was clamped for 1 h. Then, the clamp was opened and reperfusion was started for 2 h. After the termination of the experimental prosses, all animals were sacrificed and intestinal tissue samples were collected. Results: It was seen that TOS, OSI, MDA levels and MPO activity increased in mesenteric ischemia-reperfusion group compared to sham group. Moreover, SOD activity and TAS level reduced in mesenteric ischemia-reperfusion group compared to sham group. When compared to mesenteric ischemia-reperfusion group, TAS value and SOD activity increased while TOS, OSI values, MPO activity and MDA level decreased in groups treated with low and high doses of evodiamine (10 and 20 mg/kg). Conclusion: Two different doses of evodiamine revealed benefical effects against oxidative damage of intestinal tissue induced by mesenteric ischemia-reperfusion.