Makale detayı · 2025
Therapeutic Potential of Cepharanthine in Ovarian Ischemia-Reperfusion Injury: Insights from a Rat Ovarian Torsion-Detorsion Model
Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
- Yıl
- 2025
- ISSN
2791-8645- Tür
- article
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Özet
İngilizce (OpenAlex)
This study evaluated the potential protective effects of Cepharanthine (CEP) in mitigating ischemia-reperfusion (I/R) injury of an ovarian torsion/detorsion (T/D) rat model. Twenty-four female Sprague-Dawley rats were randomized into three experimental groups: sham, T/D, and CEP 10 mg/kg. The study examined ovarian tissue samples to measure oxidative stress biomarkers, such as malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD), as well as proinflammatory mediators, specifically tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). The T/D group exhibited significant oxidative stress, characterized by elevated MDA and MPO levels and low SOD activity, along with heightened inflammatory responses, as indicated by elevated TNF-α and IL-1β levels (p
Konular
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
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Birincil konu Natural product bioactivities and synthesis