Makale detayı · 2018 · article
Evaluation of chalcones as inhibitors of glutathione S-transferase
Veri kaynağı ayrımı
- YÖKSİSYÖKSİS makale kaydı
- YÖKSİS dergi adıJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Katalog eşleşmesi (ISSN)Journal of Biochemical and Molecular Toxicology
- OpenAlexOpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
Abstract Glutathione S‐transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were tested against human GST. For this purpose, GST was purified from human erythrocytes with 5.381 EU⋅mg−1 specific activity and 51.95% yield using a GSH–agarose affinity chromatographic method. The effects of chalcones on in vitro GST activity were tested at various concentrations. Ki constants of chalcones were found in the range of 7.76–41.93 μM. According to the results, 4‐fluorochalcone showed a better inhibitory effect compared with the other compounds. The inhibition mechanisms of 2'‐hydroxy‐4‐methoxychalcone and 4‐methoxychalcone were noncompetitive, whereas the inhibition mechanisms of 4'‐ hydroxychalcone, 4‐ fluorochalcone, and 4,4'‐ diflurochalcone were competitive.
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Yerel katalogda bu makaleye atıf yapan 128 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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