İçeriğe geç
akaturk Akademik ölçüm
Giriş yap Kayıt ol

Makale detayı · 2022

Biological Activity Evaluation of Novel Monoamine Oxidase Inhibitory Compounds Targeting Parkinson Disease

Dergi

FUTURE MEDICINAL CHEMİSTRY

ISSN 1756-8919

ISSN kaydı başka bir dergiye işaret ediyor; ad YÖKSİS kaydından.

YÖKSİS OpenAlex SJR Q2 JCR Q2 Atıf 8 Yüzdelik 66.7% FWCI 0.79
Yıl
2022
DOI
10.4155/fmc-2022-0167
Tür
article

Veri kaynağı ayrımı

  • YÖKSİS YÖKSİS makale kaydı
  • YÖKSİS dergi adı FUTURE MEDICINAL CHEMİSTRY
  • Katalog eşleşmesi (ISSN) Future Medicinal Chemistry
  • OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)

OpenAlex kaydı

Özet

OpenAlex · İngilizce

Aim: Design of 5-methoxy benzofuran hybrids with 2-carbohydrazide and 2-(1,3,4-oxadiazol-2-yl) as potential inhibitors of monoamine oxidase (MAO)-B targeting Parkinson disease. Materials and methods: 12 compounds were synthesized and analyzed via high-resolution mass spectrometry, 1H nuclear magnetic resonance and 13C nuclear magnetic resonance techniques. In vitro fluorometric assay was used to investigate the activity of the synthesized compounds on both MAO-A and MAO-B isozymes. Results: Three compounds – 3a, 3c and 3e – displayed half maximal inhibitory concentration values of 0.051 ± 0.002, 0.038 ± 0.001 and 0.077 ± 0.003 μM in the inhibition of MAO-A and 0.048 ± 0.002, 0.040 ± 0.001 and 0.072 ± 0.002 μM for MAO-B, respectively. A molecular dynamics simulation study showed that compound 3c has poor stability as a complex with MAO-A. Conclusion: Compound 3c may be a potential candidate for the treatment of Parkinson disease.

Konular

Atıflar

OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.

8 atıf

OpenAlex cited_by_count (önbellek / veritabanı)

Yerel katalogda bu makaleye atıf yapan 25 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).

  1. Antimicrobial Activity of Novel Substituted 1,2,4- Triazole and 1,3-Thiazole Derivatives 2024 Atıf 25 · OpenAlex
  2. Antimicrobial activity of novel substituted 1,2,4-triazole and 1,3-thiazole derivatives 2024 Atıf 24 · OpenAlex
  3. Antimicrobial activity of novel substituted 1,2,4-triazole and 1,3-thiazole derivatives 2024 Atıf 24 · OpenAlex
  4. Pharmacophore‐Based Modeling, Synthesis, and Biological Evaluation of Novel Quinazoline/Quinoline Derivatives: Discovery of EGFR Inhibitors with Low Nanomolar Activity 2025 Atıf 13 · OpenAlex
  5. Novel oxadiazole-thiadiazole derivatives: synthesis, biological evaluation, and in silico studies 2024 Atıf 12 · OpenAlex
  6. Design and synthesis of phenoxy methyl‐oxadiazole compounds against Alzheimers disease 2024 Atıf 12 · OpenAlex
  7. Design and synthesis of phenoxy methyl‐oxadiazole compounds against Alzheimers disease 2024 Atıf 12 · OpenAlex
  8. Design and synthesis of phenoxy methyl‐oxadiazole compounds against Alzheimers disease 2024 Atıf 12 · OpenAlex
  9. Design and synthesis of phenoxy methyl‐oxadiazole compounds against Alzheimers disease 2024 Atıf 12 · OpenAlex
  10. Novel oxadiazole-thiadiazole derivatives: synthesis, biological evaluation, and in silico studies 2023 Atıf 12 · OpenAlex

Yazarlar

  1. SAM DAWBAA
  2. ASAF EVRİM EVREN
  3. BEGÜM NURPELİN SAĞLIK ÖZKAN
  4. NALAN GÜNDOĞDU KARABURUN ANADOLU ÜNİVERSİTESİ
  5. AHMET ÇAĞRI KARABURUN