Phytochemical profiles and Bioactivity of Nepeta phyllochlamys PH Davis

OpenAlex İngilizce

There are about 275 taxa of Nepeta L. in the world [ 1 ]. In Turkey, Nepeta includes 45 taxa, 18 of which are endemic [ 2 ]. Nepeta species are widely used in folk medicine because of their antispasmodic, diuretic, antiseptic, antitussive, antiasthmatic, and febrifuge activities [ 3 ]. Nepeta phyllochlamys P. H. Davis is a local endemic in Antalya province, Turkey. This study aimed to in vitro antioxidant and antimicrobial activity of extracts prepared with different solvents (n-hexane, ethyl alcohol 70%, and ethyl acetate) of N. phyllochlamys . The antioxidant activities of the extracts of N . phyllochlamys were determined by the DPPH• scavenging activity assay. Furthermore, the composition of hydrodistilled essential oil (yield 0.7%.) of N. phyllochlamys was determined by GC/GC-MS analysis. 70% ethanol extract of N. phyllochlamys showed higher antioxidant activity (IC 50 : 0.32 ± 0.025 mg/ml). However, all extracts of the N. phyllochlamys demonstrated weaker antioxidant activity than the standard gallic acid. According to the GC-MS analysis, the major components were determined as caryophyllene oxide (%18.2), β-pinene (%15.6) and linalool (%11.0). N. phyllochlamys extracts were evaluated against four bacterial and five candidal reference strains. The extracts showed weak activity against all bacterial strains in the MIC range of 2000 – 8000 µg/mL. It was determined that the lowest MIC value (125 µg/mL) and the highest anticandidal effect were in n-hexane extract against C. tropicalis (ATCC750). Publication History Article published online: 12 December 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany